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Nitric Oxide plays a crucial role in the immune system and is utilized as an effector molecule by macrophages to kill fungi, viruses, bacteria, protozoa, helminths, and rickettsiae. If an animal's ability to produce Nitric Oxide is reduced, it impairs the animals ability to fight infection. Increased exposure to pathogens, increases an animal's need to produce Nitric Oxide.

Nitric Oxide can be depleted by an animal's efforts to resist infection. Additionally, certain pathogens defend themselves against attack by macrophages by releasing chemicals such as aflatoxin, which inhibit the release of Nitric Oxide. In either case, to maximize an animal's ability to fight pathogenic organisms it is important to support production of Nitric Oxide.

Since Nitric Oxide dilates blood vessels and is involved in a variety of other functions affecting every system of the body, depletion of Nitric Oxide can have far ranging adverse effects. During pregnancy Nitric Oxide is needed to insure proper blood supply to the placenta and the developing fetus. Since Nitric Oxide is needed for proper blood flow throughout the gastrointestinal system, insufficient levels of Nitric Oxide could adversely affect a foal's growth and development.

Due to the complexity of the immunological processes involved in defending against pathogens, conventional approaches to developing vaccines against infection have met with limited success. The development of infection-fighting agents has now begun to focus on effector molecules such as Nitric Oxide. Rather than attempting to mimic the body's immune responses with antibiotics or other synthetic agents, supporting an animal's innate immune mechanisms may produce better results.

Nitric Oxide is produced by macrophages from the amino acid arginine. ImmunoPLUS™ is a dietary supplement that combines arginine with a proprietary blend of all-natural ingredients that is designed to promote production of Nitric Oxide. Promoting production of Nitric Oxide supports a horse’s ability to fight fungi, viruses, bacteria, protozoa, helminths, and rickettsiae.