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The Science:

Nitric Oxide stimulates the release of cyclic GMP, which results in vasodilation. Insufficient functioning of the Nitric Oxide-cyclic GMP pathway has been implicated in the pathogenesis of conditions such as erectile dysfunction, myocardial ischemia, and asthma. Previously, attending such conditions require the use of pharmaceutical agents that either donate nitric oxide directly (i.e. nitroglycerin), or inhibit the enzymatic breakdown of cyclic GMP, (i.e. Viagra/sildenafil).

However, such pharmaceutical agents are incapable of increasing endogenous synthesis of Nitric Oxide. Thus, pharmaceutical agents utilized to compensate for insufficient nitric oxide production are incapable of correcting the underlying deficiency for which they are commonly prescribed. Rather than attempting to inhibit the breakdown of cyclic GMP or donating Nitric Oxide itself, a logical alternative strategy would be to promote increased synthesis of Nitric Oxide.

Nitric Oxide is synthesized in the body from its nutrient precursor, the amino acid arginine. Attempts to increase nitric oxide production through the oral administration of large quantities of arginine have met with limited success. Additionally, administration of large amounts of arginine may have undesirable side effects, either through stimulating insulin release or by affecting other mechanisms.

Thus, there has existed a need for a way of increasing Nitric Oxide synthesis within the body using relatively small doses of arginine. Achieving these previously unattainable results was made possible through the development of a proprietary product formulation methodology, known as NPS.

NPS™ stands for "Neurotransmitter Production Support". This approach to product formulation is designed to systematically promote synergistic interactions of specific ingredients.

A specific conceptual framework guided the development of a nutritional product that could significantly aid in the recovery from laminitis. This conceptual framework is an integral component of the NPS™ formulation methodology.

NitrOxidePLUS™ provides the nutrients a horse’s body needs to form neurotransmitters that promote blood flow. NitrOxidePLUS™ combines selected neurotransmitter-precursors with all-natural ingredients that support neurotransmitter synthesis.